Deubiquitinase JOSD1 tempers hepatic proteotoxicity
Abstract Derangements in protein homeostasis and associated proteotoxicity mark acute, chronic, and drug-induced hepatocellular injury.Metabolic dysfunction-associated proteasomal inhibition and the use of proteasome inhibitors often underlie such pathological hepatic proteotoxicity.In this study, we sought to identify a candidate deubiquitinating